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Globin switches in yolk sac–like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells

We have previously shown that coculture of human embryonic stem cells (hESCs) for 14 days with immortalized fetal hepatocytes yields CD34(+) cells that can be expanded in serum-free liquid culture into large numbers of megaloblastic nucleated erythroblasts resembling yolk sac–derived cells. We show...

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Autors principals: Qiu, Caihong, Olivier, Emmanuel N., Velho, Michelle, Bouhassira, Eric E.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234066/
https://ncbi.nlm.nih.gov/pubmed/18024790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-102087
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