Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development

We elucidate the cellular and molecular kinetics of the stepwise differentiation of human embryonic stem cells (hESCs) to primitive and definitive erythromyelopoiesis from human embryoid bodies (hEBs) in serum-free clonogenic assays. Hematopoiesis initiates from CD45 hEB cells with emergence of semi...

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Autors principals: Zambidis, Elias T., Peault, Bruno, Park, Tea Soon, Bunz, Fred, Civin, Curt I.
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2005
Matèries:
Hematopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895146/
https://ncbi.nlm.nih.gov/pubmed/15831705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4522
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