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Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development

We elucidate the cellular and molecular kinetics of the stepwise differentiation of human embryonic stem cells (hESCs) to primitive and definitive erythromyelopoiesis from human embryoid bodies (hEBs) in serum-free clonogenic assays. Hematopoiesis initiates from CD45 hEB cells with emergence of semi...

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Detalhes bibliográficos
Main Authors: Zambidis, Elias T., Peault, Bruno, Park, Tea Soon, Bunz, Fred, Civin, Curt I.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895146/
https://ncbi.nlm.nih.gov/pubmed/15831705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4522
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