Arachidonic Acid Inhibits Epithelial Na Channel Via Cytochrome P450 (CYP) Epoxygenase-dependent Metabolic Pathways

We used the patch-clamp technique to study the effect of arachidonic acid (AA) on epithelial Na channels (ENaC) in the rat cortical collecting duct (CCD). Application of 10 μM AA decreased the ENaC activity defined by NPo from 1.0 to 0.1. The dose–response curve of the AA effect on ENaC shows that 2...

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Main Authors: Wei, Yuan, Lin, Dao-Hong, Kemp, Rowena, Yaddanapudi, Ganesh S.S., Nasjletti, Alberto, Falck, John R., Wang, Wen-Hui
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234027/
https://ncbi.nlm.nih.gov/pubmed/15545402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409140
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