Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways

We used the patch-clamp technique to study the effect of arachidonic acid (AA) on basolateral 18-pS K channels in the principal cell of the cortical collecting duct (CCD) of the rat kidney. Application of AA inhibited the 18-pS K channels in a dose-dependent manner and 10 μM AA caused a maximal inhi...

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Bibliographic Details
Main Authors: Wang, ZhiJian, Wei, Yuan, Falck, John R., Atcha, Krishnam Raju, Wang, Wen-Hui
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734470/
https://ncbi.nlm.nih.gov/pubmed/18417544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00038.2008
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