Arachidonic Acid Inhibits Epithelial Na Channel Via Cytochrome P450 (CYP) Epoxygenase-dependent Metabolic Pathways

We used the patch-clamp technique to study the effect of arachidonic acid (AA) on epithelial Na channels (ENaC) in the rat cortical collecting duct (CCD). Application of 10 μM AA decreased the ENaC activity defined by NPo from 1.0 to 0.1. The dose–response curve of the AA effect on ENaC shows that 2...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Wei, Yuan, Lin, Dao-Hong, Kemp, Rowena, Yaddanapudi, Ganesh S.S., Nasjletti, Alberto, Falck, John R., Wang, Wen-Hui
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2004
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234027/
https://ncbi.nlm.nih.gov/pubmed/15545402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409140
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk