Alterations of the p16-pRb Pathway and the Chromosome Locus 9p21–22 in Non-Small-Cell Lung Carcinomas : Relationship with p53 and MDM2 Protein Expression

The p16-pRb and p53-MDM2 pathways represent vital cell cycle checkpoints. Recent studies provide evidence that these pathways are directly linked via MDM2-pRb interaction and p53 suppression of the RB1 gene. In the present study we investigated the alterations of this G1 phase protein network using...

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Hauptverfasser: Gorgoulis, Vassilis G., Zacharatos, Panayotis, Kotsinas, Athanassios, Liloglou, Triantofillos, Kyroudi, Aspasia, Veslemes, Marinos, Rassidakis, Antonios, Halazonetis, Thanos D., Field, John K., Kittas, Christos
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 1998
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233978/
https://ncbi.nlm.nih.gov/pubmed/9846966
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