Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene.

The present study represents a continuation of previous works in which we observed that lung carcinomas co-expressing MDM2 protein and p53 mutants (mt p53) exhibited more aggressive behaviour. In the above studies, we suggested a 'gain of function' mechanism of mt p53 proteins based on the...

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Detalhes bibliográficos
Main Authors: Gorgoulis, V. G., Zacharatos, P. V., Manolis, E., Ikonomopoulos, J. A., Damalas, A., Lamprinopoulos, C., Rassidakis, G. Z., Zoumpourlis, V., Kotsinas, A., Rassidakis, A. N., Halazonetis, T. D., Kittas, C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151306/
https://ncbi.nlm.nih.gov/pubmed/9472631
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