Low levels of p27 in association with deregulated p53-pRb protein status enhance tumor proliferation and chromosomal instability in non-small cell lung carcinomas.

BACKGROUND: Down-regulation or overexpression of the cyclin-dependent kinase inhibitor p27 have been observed in a range of malignancies, including lung cancer. To further elucidate the role of the molecule in tumor growth regulation, we evaluated p27 expression in a series of non-small cell lung ca...

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Hauptverfasser: Tsoli, E., Gorgoulis, V. G., Zacharatos, P., Kotsinas, A., Mariatos, G., Kastrinakis, N. G., Kokotas, S., Kanavaros, P., Asimacopoulos, P., Bramis, J., Kletsas, D., Papavassiliou, A. G., Kittas, C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2001
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950049/
https://ncbi.nlm.nih.gov/pubmed/11474135
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