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Stabilizing the Closed S6 Gate in the Shaker K (v) Channel Through Modification of a Hydrophobic Seal
The primary activation gate in K(+) channels is thought to reside near the intracellular entrance to the ion conduction pore. In a previous study of the S6 activation gate in Shaker (Hackos et al., 2002), we found that mutation of V478 to W results in a channel that cannot conduct ions even though t...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Rockefeller University Press
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2233904/ https://ncbi.nlm.nih.gov/pubmed/15365093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409098 |
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