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Stabilizing the Closed S6 Gate in the Shaker K (v) Channel Through Modification of a Hydrophobic Seal

The primary activation gate in K(+) channels is thought to reside near the intracellular entrance to the ion conduction pore. In a previous study of the S6 activation gate in Shaker (Hackos et al., 2002), we found that mutation of V478 to W results in a channel that cannot conduct ions even though t...

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Bibliografiske detaljer
Main Authors: Kitaguchi, Tetsuya, Sukhareva, Manana, Swartz, Kenton J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233904/
https://ncbi.nlm.nih.gov/pubmed/15365093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409098
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