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Stabilizing the Closed S6 Gate in the Shaker K (v) Channel Through Modification of a Hydrophobic Seal
The primary activation gate in K(+) channels is thought to reside near the intracellular entrance to the ion conduction pore. In a previous study of the S6 activation gate in Shaker (Hackos et al., 2002), we found that mutation of V478 to W results in a channel that cannot conduct ions even though t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2233904/ https://ncbi.nlm.nih.gov/pubmed/15365093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409098 |
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