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Voltage-Controlled Gating at the Intracellular Entrance to a Hyperpolarization-Activated Cation Channel

Hyperpolarization-activated cation (HCN) channels regulate pacemaking activity in cardiac cells and neurons. Our previous work using the specific HCN channel blocker ZD7288 provided evidence for an intracellular activation gate for these channels because it appears that ZD7288, applied from the intr...

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Détails bibliographiques
Auteurs principaux: Rothberg, Brad S., Shin, Ki Soon, Phale, Prashant S., Yellen, Gary
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2002
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233860/
https://ncbi.nlm.nih.gov/pubmed/11773240
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