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Single-channel SCAM Identifies Pore-lining Residues in the First Extracellular Loop and First Transmembrane Domains of Cx46 Hemichannels

Gap junction (GJ) channels provide an important pathway for direct intercellular transmission of signaling molecules. Previously we showed that fixed negative charges in the first extracellular loop domain (E1) strongly influence charge selectivity, conductance, and rectification of channels and hem...

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Bibliografiske detaljer
Main Authors: Kronengold, J., Trexler, E.B., Bukauskas, F.F., Bargiello, T.A., Verselis, V.K.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233777/
https://ncbi.nlm.nih.gov/pubmed/12975451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308861
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