A defect in skeletal muscle sodium channel deactivation exacerbates hyperexcitability in human paramyotonia congenita

1. Paramyotonia congenita (PC) is a human hereditary disorder wherein missense mutations in the skeletal muscle sodium channel lead to cold-exacerbated muscle hyperexcitability. The most common site for PC mutations is the outermost arginine of domain IV segment 4 (human R1448, rat R1441). 2. We exa...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Featherstone, David E, Fujimoto, Esther, Ruben, Peter C
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Science Inc 1998
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230742/
https://ncbi.nlm.nih.gov/pubmed/9503326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1998.627bv.x
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk