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Zn(2+) inhibition of recombinant GABA(A) receptors: an allosteric, state-dependent mechanism determined by the γ-subunit
1. The γ-subunit in recombinant γ-aminobutyric acid (GABA(A)) receptors reduces the sensitivity of GABA-triggered Cl(−) currents to inhibition by Zn(2+) and transforms the apparent mechanism of antagonism from non-competitive to competitive. To investigate underlying receptor function we studied Zn(...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Science Inc
1998
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2230740/ https://ncbi.nlm.nih.gov/pubmed/9503325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1998.609bv.x |
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