Zn(2+) inhibition of recombinant GABA(A) receptors: an allosteric, state-dependent mechanism determined by the γ-subunit

1. The γ-subunit in recombinant γ-aminobutyric acid (GABA(A)) receptors reduces the sensitivity of GABA-triggered Cl(−) currents to inhibition by Zn(2+) and transforms the apparent mechanism of antagonism from non-competitive to competitive. To investigate underlying receptor function we studied Zn(...

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Detaylı Bibliyografya
Asıl Yazarlar: Gingrich, K J, Burkat, P M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 1998
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230740/
https://ncbi.nlm.nih.gov/pubmed/9503325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1998.609bv.x
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