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A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation

Renin, a major regulatory component of the renin-angiotensin system, plays a pivotal role in regulating blood pressure and electrolyte homeostasis and is predominantly expressed in the kidney. Several cAMP-responsive elements have been identified within renin gene promoters. Here, we study how 2 suc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tanimoto, Keiji, Sugiura, Akiko, Kanafusa, Sumiyo, Saito, Tomoko, Masui, Naoto, Yanai, Kazuyuki, Fukamizu, Akiyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230662/
https://ncbi.nlm.nih.gov/pubmed/18259612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33824
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