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Homeostatic Response of Mouse renin Gene Transcription in a Hypertensive Environment Is Mediated by a Novel 5′ Enhancer

The renin-angiotensin system plays an essential role in blood pressure homeostasis. Because renin activity is reflected as a blood pressure phenotype, its gene expression in the kidney is tightly regulated by a feedback mechanism; i.e., renin gene transcription is suppressed in a hypertensive state....

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Ushiki, Aki, Matsuzaki, Hitomi, Fukamizu, Akiyoshi, Tanimoto, Keiji
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854831/
https://ncbi.nlm.nih.gov/pubmed/29358217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00566-17
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