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Movement of Voltage Sensor S4 in Domain 4 Is Tightly Coupled to Sodium Channel Fast Inactivation and Gating Charge Immobilization

The highly charged transmembrane segments in each of the four homologous domains (S4D1–S4D4) represent the principal voltage sensors for sodium channel gating. Hitherto, the existence of a functional specialization of the four voltage sensors with regard to the control of the different gating modes,...

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Autori principali: Kühn, Frank J.P., Greeff, Nikolaus G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230646/
https://ncbi.nlm.nih.gov/pubmed/10435996
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