Circular antisense oligonucleotides inhibit growth of chronic myeloid leukemia cells.

BACKGROUND: Antisense represents a conceptually powerful method for regulating gene expression. However, antisense oligonucleotides developed to date manifest two serious limitations-nuclease susceptibility and nonspecific hybridization. Circular oligonucleotides may be superior to conventional line...

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Autori principali: Rowley, P. T., Kosciolek, B. A., Kool, E. T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Feinstein Institute for Medical Research 1999
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230474/
https://ncbi.nlm.nih.gov/pubmed/10602778
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