Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein.

BACKGROUND: Aberrant metabolism of the Alzheimer amyloid precursor protein (APP) or its amyloidogenic A beta fragment is thought to be centrally involved in Alzheimer's disease. Nonamyloidogenic processing of APP involves its cleavage within the A beta domain by a protease, termed alpha-secreta...

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Hauptverfasser: da Cruz e Silva, E. F., da Cruz e Silva, O. A., Zaia, C. T., Greengard, P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Feinstein Institute for Medical Research 1995
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229959/
https://ncbi.nlm.nih.gov/pubmed/8529119
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