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Elimination of the Slow Gating of Clc-0 Chloride Channel by a Point Mutation

The inactivation of the ClC-0 chloride channel is very temperature sensitive and is greatly facilitated by the binding of a zinc ion (Zn(2+)) from the extracellular side, leading to a Zn(2+)-induced current inhibition. To further explore the relation of Zn(2+) inhibition and the ClC-0 inactivation,...

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Autori principali: Lin, Yu-Wen, Lin, Chia-Wei, Chen, Tsung-Yu
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229640/
https://ncbi.nlm.nih.gov/pubmed/10398688
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