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Proton-dependent inhibition, inverted voltage activation, and slow gating of CLC-0 Chloride Channel
CLC-0, a prototype Cl(-) channel in the CLC family, employs two gating mechanisms that control its ion-permeation pore: fast gating and slow gating. The negatively-charged sidechain of a pore glutamate residue, E166, is known to be the fast gate, and the swinging of this sidechain opens or closes th...
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| Veröffentlicht in: | PLoS One |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7757909/ https://ncbi.nlm.nih.gov/pubmed/33362212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0240704 |
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