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Voltage and Ca(2+) Activation of Single Large-Conductance Ca(2+)-Activated K(+) Channels Described by a Two-Tiered Allosteric Gating Mechanism

The voltage- and Ca(2+)-dependent gating mechanism of large-conductance Ca(2+)-activated K(+) (BK) channels from cultured rat skeletal muscle was studied using single-channel analysis. Channel open probability (P (o)) increased with depolarization, as determined by limiting slope measurements (11 mV...

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Bibliografiske detaljer
Main Authors: Rothberg, Brad S., Magleby, Karl L.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229615/
https://ncbi.nlm.nih.gov/pubmed/10871641
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