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Voltage and Ca(2+) Activation of Single Large-Conductance Ca(2+)-Activated K(+) Channels Described by a Two-Tiered Allosteric Gating Mechanism
The voltage- and Ca(2+)-dependent gating mechanism of large-conductance Ca(2+)-activated K(+) (BK) channels from cultured rat skeletal muscle was studied using single-channel analysis. Channel open probability (P (o)) increased with depolarization, as determined by limiting slope measurements (11 mV...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2229615/ https://ncbi.nlm.nih.gov/pubmed/10871641 |
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