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Mutation-induced Blocker Permeability and Multiion Block of the CFTR Chloride Channel Pore
Chloride permeation through the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel is blocked by a broad range of anions that bind tightly within the pore. Here we show that the divalent anion Pt(NO(2))(4) (2−) acts as an impermeant voltage-dependent blocker of the CFTR pore wh...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Rockefeller University Press
2003
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2229596/ https://ncbi.nlm.nih.gov/pubmed/14610019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308889 |
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