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Spontaneous Channel Activity of the Inositol 1,4,5-Trisphosphate (InsP(3)) Receptor (InsP(3)R). Application of Allosteric Modeling to Calcium and InsP(3) Regulation of InsP(3)R Single-channel Gating
The InsP(3)R Ca(2+) release channel has a biphasic dependence on cytoplasmic free Ca(2+) concentration ([Ca(2+)](i)). InsP(3) activates gating primarily by reducing the sensitivity of the channel to inhibition by high [Ca(2+)](i). To determine if relieving Ca(2+) inhibition is sufficient for channel...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2229577/ https://ncbi.nlm.nih.gov/pubmed/14581584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308809 |
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