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On the Structural Basis for Size-selective Permeation of Organic Cations through the Voltage-gated Sodium Channel : Effect of Alanine Mutations at the DEKA Locus on Selectivity, Inhibition by Ca(2+) and H(+), and Molecular Sieving
Recent evidence indicates that ionic selectivity in voltage-gated Na(+) channels is mediated by a small number of residues in P-region segments that link transmembrane elements S5 and S6 in each of four homologous domains denoted I, II, III, and IV. Important determinants for this function appear to...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2229404/ https://ncbi.nlm.nih.gov/pubmed/9382897 |
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