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Tetracaine Reports a Conformational Change in the Pore of Cyclic Nucleotide–gated Channels

Local anesthetics are a diverse group of clinically useful compounds that act as pore blockers of both voltage- and cyclic nucleotide–gated (CNG) ion channels. We used the local anesthetic tetracaine to probe the nature of the conformational change that occurs in the pore of CNG channels during the...

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Main Authors: Fodor, Anthony A., Black, Kevin D., Zagotta, William N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 1997
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229390/
https://ncbi.nlm.nih.gov/pubmed/9348330
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