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Cyclic Nucleotide-Gated Channel Block by Hydrolysis-Resistant Tetracaine Derivatives
To meet a pressing need for better cyclic nucleotide-gated (CNG) channel antagonists, we have increased the biological stability of tetracaine-based blockers by synthesizing amide and thioamide linkage substitutions of tetracaine (1) and a higher affinity octyl tail derivative (5). We report the app...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3132207/ https://ncbi.nlm.nih.gov/pubmed/21634421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200495g |
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