Effects of Lovastatin on Rho Isoform Expression, Activity, and Association with Guanine Nucleotide Dissociation Inhibitors

3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (EC1.1.1.88) inhibitors (statins) reduce cholesterol synthesis and prevent cardiovascular disease; they can also inhibit prenylation of Ras and Rho proteins, and have anti-neoplastic effects. Rho proteins cycle between an active, GTP-bound, a...

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Main Authors: Turner, Stephanie J., Zhuang, Shunhui, Zhang, Tong, Boss, Gerry R., Pilz, Renate B.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228324/
https://ncbi.nlm.nih.gov/pubmed/17920041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.08.031
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