TROY Interacts with Rho Guanine Nucleotide Dissociation Inhibitor α (RhoGDIα) to Mediate Nogo-induced Inhibition of Neurite Outgrowth

TROY can functionally substitute p75 to comprise the Nogo receptor complex, which transduces the inhibitory signal of myelin-associated inhibitory factors on axon regeneration following CNS injury. The inhibition of neurite extension relies on TROY-dependent RhoA activation, but how TROY activates R...

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Main Authors: Lu, Yan, Liu, Xiujie, Zhou, Jianfeng, Huang, Aijun, Zhou, Jiazhen, He, Cheng
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Neurobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837168/
https://ncbi.nlm.nih.gov/pubmed/24129566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.519744
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