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Receptor downregulation and desensitization enhance the information processing ability of signalling receptors

BACKGROUND: In addition to initiating signaling events, the activation of cell surface receptors also triggers regulatory processes that restrict the duration of signaling. Acute attenuation of signaling can be accomplished either via ligand-induced internalization of receptors (endocytic downregula...

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Autori principali: Shankaran, Harish, Wiley, H Steven, Resat, Haluk
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228318/
https://ncbi.nlm.nih.gov/pubmed/17996096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-1-48
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