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Gene expression profiling of leukemic cells and primary thymocytes predicts a signature for apoptotic sensitivity to glucocorticoids

BACKGROUND: Glucocorticoids (GC's) play an integral role in treatment strategies designed to combat various forms of hematological malignancies. GCs also are powerful inhibitors of the immune system, through regulation of appropriate cytokines and by causing apoptosis of immature thymocytes. By...

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Autori principali: Miller, Aaron L, Komak, Spogmai, Webb, M Scott, Leiter, Edward H, Thompson, E Brad
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228275/
https://ncbi.nlm.nih.gov/pubmed/18045478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-7-18
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