Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the...

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Autori principali: van Asperen, J., van Tellingen, O., Sparreboom, A., Schinkel, A. H., Borst, P., Nooijen, W. J., Beijnen, J. H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1997
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228133/
https://ncbi.nlm.nih.gov/pubmed/9365166
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