Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells.

Recently, many inhibitors of farnesyl protein transferase (FPTase) have been identified. Some of them interrupt cell growth in addition to Ras and nuclear lamin processing of Ras-transformed cells. We have tested the effect of the FPTase inhibitors manumycin, an analogue of farnesyl diphosphate, and...

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Détails bibliographiques
Auteurs principaux: Nagase, T., Kawata, S., Tamura, S., Matsuda, Y., Inui, Y., Yamasaki, E., Ishiguro, H., Ito, T., Miyagawa, J., Mitsui, H., Yamamoto, K., Kinoshita, M., Matsuzawa, Y.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 1997
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228099/
https://ncbi.nlm.nih.gov/pubmed/9376258
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