Suppression of Human Pancreatic Cancer Growth in BALB/c Nude Mice by Manumycin, a Farnesyl:protein Transferase Inhibitor

Activating mutations of Ki‐ras have been detected in most human pancreatic adenocarcinomas. Since Ras protein requires farnesylation to function, we investigated the effects of manumycin, a potent farnesyl:protein transferase inhibitor, on the growth in nude mice of a human pancreatic cancer cell li...

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Publicat a:Jpn J Cancer Res
Autors principals: Ito, Toshio, Kawata, Sumio, Tamura, Shinji, Igura, Takumi, Nagase, Toshihiko, Miyagawa, Jun‐ichiro, Yamazaki, Eiji, Ishiguro, Hiroshi, Matsuzawa, Yuji
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 1996
Matèries:
Rapid Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921057/
https://ncbi.nlm.nih.gov/pubmed/8609057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1996.tb03146.x
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