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An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours.

A new in vitro model has been developed for investigating extravascular diffusion of therapeutic agents in tumour tissue. V79-171b or EMT6/Ak cells are grown on porous Teflon support membranes and submerged in a large reservoir of medium, to give diffusion-limited 'multicellular membranes'...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hicks, K. O., Ohms, S. J., van Zijl, P. L., Denny, W. A., Hunter, P. J., Wilson, W. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1997
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228074/
https://ncbi.nlm.nih.gov/pubmed/9328149
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