DDP-induced cytotoxicity is not influenced by p53 in nine human ovarian cancer cell lines with different p53 status.

Nine human ovarian cancer cell lines that express wild-type (wt) or mutated (mut) p53 were used to evaluate the cytotoxicity induced by cisplatin (DDP). The concentrations inhibiting the growth by 50% (IC50) were calculated for each cell line, and no differences were found between cells expressing w...

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Main Authors: De Feudis, P., Debernardis, D., Beccaglia, P., Valenti, M., Graniela Siré, E., Arzani, D., Stanzione, S., Parodi, S., D'Incalci, M., Russo, P., Broggini, M.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2227984/
https://ncbi.nlm.nih.gov/pubmed/9275024
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