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Driving p53 Response to Bax Activation Greatly Enhances Sensitivity to Taxol by Inducing Massive Apoptosis

The proapoptotic gene bax is one of the downstream effectors of p53. The p53 binding site in the bax promoter is less responsive to p53 than the one in the growth arrest mediating gene p21. We introduced the bax gene under the control of 13 copies of a strong p53 responsive element into two ovarian...

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書誌詳細
主要な著者: De Feudis, Paola, Vignati, Sara, Rossi, Cosmo, Mincioni, Tatiana, Giavazzi, Raffaella, D'Incalci, Maurizio, Broggini, Massimo
フォーマット: Artigo
言語:Inglês
出版事項: Nature America, Inc. 2000
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1507571/
https://ncbi.nlm.nih.gov/pubmed/10935506
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