Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP

Human MutT homologue 1 (hMTH1) hydrolyzes a variety of oxidized purine nucleoside triphosphates, including 8-oxo-dGTP, 2-oxo-dATP, 2-oxo-ATP and 8-­oxo-dATP, to their corresponding nucleoside monophosphates, while Esherichia coli MutT possesses prominent substrate specificity for 8-oxoguanine nucleo...

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Main Authors: Nakamura, Teruya, Kitaguchi, Yuki, Miyazawa, Masayuki, Kamiya, Hiroyuki, Toma, Sachiko, Ikemizu, Shinji, Shirakawa, Masahiro, Nakabeppu, Yusaku, Yamagata, Yuriko
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2006
Assuntos:
Crystallization Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225359/
https://ncbi.nlm.nih.gov/pubmed/17142918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309106049529
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