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Receptor-mediated uptake of an extracellular Bcl-x(L) fusion protein inhibits apoptosis

Bcl-x(L), a member of the Bcl-2 family, inhibits many pathways of apoptosis when overexpressed in the cell cytosol. We examined the capacity of Bcl-x(L) fusion proteins to bind cells from the outside and block apoptosis. Full-length Bcl-x(L) protein at micromolar concentrations did not affect apopto...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Liu, Xiu-Huai, Castelli, JoAnn C., Youle, Richard J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1999
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22248/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10449732/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.17.9563
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