Zygomycetes Hyphae Trigger an Early, Robust Proinflammatory Response in Human Polymorphonuclear Neutrophils through Toll-Like Receptor 2 Induction but Display Relative Resistance to Oxidative Damage

Human polymorphonuclear neutrophils (HPMNs) displayed attenuated hyphal damage associated with impaired O(2)(−) release following exposure to Rhizopus oryzae versus that with Aspergillus fumigatus. Exposure of HPMNs to R. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robu...

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Detalhes bibliográficos
Main Authors: Chamilos, G., Lewis, R. E., Lamaris, G., Walsh, T. J., Kontoyiannis, D. P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224765/
https://ncbi.nlm.nih.gov/pubmed/18025115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01136-07
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