Telithromycin Resistance in Streptococcus pneumoniae Is Conferred by a Deletion in the Leader Sequence of erm(B) That Increases rRNA Methylation

A telithromycin-resistant clinical isolate of Streptococcus pneumoniae (strain P1501016) has been found to contain a version of erm(B) that is altered by a 136-bp deletion in the leader sequence. By allele replacement mutagenesis, a second strain of S. pneumoniae (PC13) with a wild-type erm(B) gene...

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Détails bibliographiques
Auteurs principaux: Wolter, Nicole, Smith, Anthony M., Farrell, David J., Northwood, John Blackman, Douthwaite, Stephen, Klugman, Keith P.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224760/
https://ncbi.nlm.nih.gov/pubmed/18056269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01074-07
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