Regions on adenylyl cyclase that are necessary for inhibition of activity by βγ and G(iα) subunits of heterotrimeric G proteins

The two large cytoplasmic domains (C1 and C2) of adenylyl cyclases (AC), when expressed separately and mixed together, reconstitute enzyme activity that can be regulated by various modulators. Therefore, we have used the C1 or its C1a subdomain and C2 regions from type I AC (ACI) and type V AC (ACV)...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wittpoth, Claus, Scholich, Klaus, Yigzaw, Yinges, Stringfield, Teresa M., Patel, Tarun B.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22246/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10449730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.17.9551
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