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Regions on adenylyl cyclase that are necessary for inhibition of activity by βγ and G(iα) subunits of heterotrimeric G proteins

The two large cytoplasmic domains (C1 and C2) of adenylyl cyclases (AC), when expressed separately and mixed together, reconstitute enzyme activity that can be regulated by various modulators. Therefore, we have used the C1 or its C1a subdomain and C2 regions from type I AC (ACI) and type V AC (ACV)...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wittpoth, Claus, Scholich, Klaus, Yigzaw, Yinges, Stringfield, Teresa M., Patel, Tarun B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22246/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10449730/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.17.9551
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