Removal of a Single N-Linked Glycan in Human Immunodeficiency Virus Type 1 gp120 Results in an Enhanced Ability To Induce Neutralizing Antibody Responses

Glycans on human immunodeficiency virus (HIV) envelope protein play an important role in infection and evasion from host immune responses. To examine the role of specific glycans, we introduced single or multiple mutations into potential N-linked glycosylation sites in hypervariable regions (V1 to V...

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Detalhes bibliográficos
Main Authors: Li, Yun, Cleveland, Bradley, Klots, Igor, Travis, Bruce, Richardson, Barbra A., Anderson, David, Montefiori, David, Polacino, Patricia, Hu, Shiu-Lok
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224603/
https://ncbi.nlm.nih.gov/pubmed/17959660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01691-07
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