Removal of a Single N-Linked Glycan in Human Immunodeficiency Virus Type 1 gp120 Results in an Enhanced Ability To Induce Neutralizing Antibody Responses

Glycans on human immunodeficiency virus (HIV) envelope protein play an important role in infection and evasion from host immune responses. To examine the role of specific glycans, we introduced single or multiple mutations into potential N-linked glycosylation sites in hypervariable regions (V1 to V...

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Hlavní autoři: Li, Yun, Cleveland, Bradley, Klots, Igor, Travis, Bruce, Richardson, Barbra A., Anderson, David, Montefiori, David, Polacino, Patricia, Hu, Shiu-Lok
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224603/
https://ncbi.nlm.nih.gov/pubmed/17959660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01691-07
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