A Single-Amino-Acid Substitution in the NS1 Protein Changes the Pathogenicity of H5N1 Avian Influenza Viruses in Mice

In this study, we explored the molecular basis determining the virulence of H5N1 avian influenza viruses in mammalian hosts by comparing two viruses, A/Duck/Guangxi/12/03 (DK/12) and A/Duck/Guangxi/27/03 (DK/27), which are genetically similar but differ in their pathogenicities in mice. To assess th...

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Detalhes bibliográficos
Main Authors: Jiao, Peirong, Tian, Guobin, Li, Yanbing, Deng, Guohua, Jiang, Yongping, Liu, Chang, Liu, Weilong, Bu, Zhigao, Kawaoka, Yoshihiro, Chen, Hualan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224464/
https://ncbi.nlm.nih.gov/pubmed/18032512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01698-07
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