A Single-Amino-Acid Substitution in the NS1 Protein Changes the Pathogenicity of H5N1 Avian Influenza Viruses in Mice

In this study, we explored the molecular basis determining the virulence of H5N1 avian influenza viruses in mammalian hosts by comparing two viruses, A/Duck/Guangxi/12/03 (DK/12) and A/Duck/Guangxi/27/03 (DK/27), which are genetically similar but differ in their pathogenicities in mice. To assess th...

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Bibliographische Detailangaben
Hauptverfasser: Jiao, Peirong, Tian, Guobin, Li, Yanbing, Deng, Guohua, Jiang, Yongping, Liu, Chang, Liu, Weilong, Bu, Zhigao, Kawaoka, Yoshihiro, Chen, Hualan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224464/
https://ncbi.nlm.nih.gov/pubmed/18032512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01698-07
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