Human Immunodeficiency Virus Type 1 gp41 Antibodies That Mask Membrane Proximal Region Epitopes: Antibody Binding Kinetics, Induction, and Potential for Regulation in Acute Infection

Two human monoclonal antibodies (MAbs) (2F5 and 4E10) against the human immunodeficiency virus type 1 (HIV-1) envelope g41 cluster II membrane proximal external region (MPER) broadly neutralize HIV-1 primary isolates. However, these antibody specificities are rare, are not induced by Env immunizatio...

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Detalhes bibliográficos
Main Authors: Alam, S. Munir, Scearce, Richard M., Parks, Robert J., Plonk, Kelly, Plonk, Steven G., Sutherland, Laura L., Gorny, Miroslaw K., Zolla-Pazner, Susan, VanLeeuwen, Stacie, Moody, M. Anthony, Xia, Shi-Mao, Montefiori, David C., Tomaras, Georgia D., Weinhold, Kent J., Karim, Salim Abdool, Hicks, Charles B., Liao, Hua-Xin, Robinson, James, Shaw, George M., Haynes, Barton F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224348/
https://ncbi.nlm.nih.gov/pubmed/17942537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00927-07
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